A Phase 2 Study of Nivolumab in Combination With Either Rucaparib, Docetaxel, or Enzalutamide in Men With Castration-resistant Metastatic Prostate Cancer. Clovis Oncology Inc. (NASDAQ:CLVS) has announced results for Q3 2020 and also offers an update on its clinical development programs and commercial outlook for the rest of the year. Our current and historic presentations are provided in the following links. This website uses cookies to improve your overall experience. This study is sponsored by the Alliance for Clinical Trials in Oncology which is part of the National Cancer Institute. The primary endpoint of the study is PFS. About Clovis Oncology. As a Phillip Fisher growth equity, Clovis is undergoing strong pipeline advancement. Clovis holds global rights for lucitanib excluding China. Recent data for a drug that inhibits these same three pathways - when combined with a PD-1 inhibitor - are extremely encouraging and represent a scientific rationale for the development of lucitanib in combination with a PD-1 inhibitor. By clicking Accept you consent to our use of cookies. By using this website without changing your cookie settings, you agree to our use of cookies. Not all patients will receive rucaparib. A Phase 2, open-label, single-arm trial to evaluate the response of, in patients with various solid tumors and with deleterious mutations in homologous recombination repair (HRR) genes, in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of. Clovis Oncology (NASDAQ: CLVS) reported Q3 sales of $38.77 million. Exploratory studies in other tumor types are also underway. By using this website without changing your cookie settings, you agree to our use of cookies. FAP-2286 and Peptide-Targeted Radionuclide Development Program. This study is part of a broad clinical collaboration with Bristol Myers Squibb. Another clinical trial with a different Clovis compound called rucaparib is being tested in combination with Bristol-Myers Squibb's immunotherapy nivolumab. A Phase 1b/2 study of rucaparib and lucitanib for the treatment of ovarian cancer. Rucaparib, an oral, small molecule inhibitor of poly (ADP-ribose) polymerase (PARP)1, 2 and 3 is being developed in multiple tumor types, including ovarian and prostate cancers, as monotherapy and in combination with other anti-cancer agents. The nivolumab + rucaparib combination in mCRPC is being conducted as an arm of a larger Bristol Myers Squibb-sponsored study. Clovis holds global rights for the discovery program and for FAP-2286 holds U.S. and global rights, excluding Europe. Use of antiangiogenic drugs may reverse this immunosuppression and augment response to immunotherapy. Clovis Oncology Announces Oral Plenary Session Presentation at International Gynecologic Cancer Society Digital Annual Global Meeting Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Patients for Treatment With Rucaparib: Next-Generation Sequencing of Cell-free Tumor DNA (ctDNA) and Tumor Tissue ARIEL4 (Assessment of Rucaparib In Ovarian CancEr TriaL): A Phase 3 Multicenter, Randomized Study of Rucaparib Versus Chemotherapy in Patients With Relapsed, BRCA Mutant, High Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. For more information, please visit www.tritontrials.com. Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Clovis was founded in 2009 and is headquartered in Boulder, Colorado. View real-time stock prices and stock quotes for a full financial overview. Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Clovis’ product development programs generally target specific subsets of cancer, and the Company seeks to simultaneously develop, with partners, diagnostic tools intended to direct a compound in development to the patients most likely to benefit from its use. Company and Drug Pipeline info for CLVS. The initial focus is on developing FAP-2286, a peptide-targeted radionuclide therapy (PTRT) and imaging agent targeting fibroblast activation protein (FAP). Clovis Oncology, Inc. (NASDAQ: CLVS) today announced the data being presented as e-posters at the European Society for Medical Oncology (ESMO) Virtual Congress 2020. This randomized, placebo-controlled phase 3 trial is evaluating the benefit of rucaparib and enzalutamide combination therapy versus enzalutamide alone for the treatment of men with prostate cancer that has spread to other places in the body (metastatic) and has become resistant to testosterone-deprivation therapy (castration-resistant). To view Encore Presentations, visit our Encore Presentations Page. Ladies and gentlemen, thank you for standing by, and welcome to the Clovis Oncology Third Quarter Financial Results Conference Call. By clicking Accept you consent to our use of cookies. To view Encore Presentations, visit our Encore Presentations Page. Clovis Oncology continues to disappoint shareholders who are hoping for a potential buyout. For more information on how we use cookies, please see our Cookie Policy and Privacy Policy. The primary endpoint of this study is PFS. As part of this study, genetic testing results will be provided. Recently, the company announced a licensing agreement with 3B Pharmaceuticals to expand the pipeline. Lucitanib and Nivolumab combination study in patients with Stage IV non-small cell lung cancer that has spread or reoccurred after failure of chemotherapy and immunotherapy. Clovis Oncology holds U.S. and global rights, excluding Europe. FAP is highly expressed in many epithelial cancers, including more than 90 percent of breast, lung, colorectal and pancreatic carcinomas.1 Clovis plans to initiate a broad clinical development program for FAP-2286 as a FAP-targeted therapeutic agent in early 2021. This website uses cookies to improve your overall experience. Emerging clinical data support the combination of angiogenesis inhibitors and immunotherapy to increase effectiveness in multiple cancer indications. Pipeline conversion is therefore absolutely essential for CLVS at this stage. Angiogenic factors, such as vascular endothelial growth factor (VEGF), are frequently up-regulated in tumors and create an immunosuppressive tumor microenvironment. Our current and historic presentations are provided in the following links. Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Clovis holds global rights for rucaparib. TRITON3: A Multicenter, Randomized, Open Label Phase 3 Study of Rucaparib Versus Physician's Choice of Therapy for Patients With Metastatic Castration Resistant Prostate Cancer Associated With Homologous Recombination Deficiency. Phase 1/2 combination study sponsored by Bristol Myers Squibb will evaluate multiple combinations with nivolumab, including an arm in combination with lucitanib, in patients with Stage IV non-small cell lung cancer that has spread or reoccurred after failure of chemotherapy and immunotherapy. Clovis Oncology's top competitors are Sysmex Inostics, Immunomedics and Bioarray Genetics, Inc.. See Clovis Oncology's revenue, employees, and funding info on Owler, the world’s largest community-based business insights platform. Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Clovis Oncology is a small pharmaceutical company which mainly markets products for treatment in oncology. 7.3 Pipeline analysis by Phases of … This study is sponsored by Bristol Myers Squibb. Clovis holds global rights for rucaparib. Clovis Oncology presents data on its products in development at a variety of medical conferences. Copyright © 2021 BY CLOVIS ONCOLOGY, ALL RIGHTS RESERVED. Phase 3 study in advanced ovarian cancer in the first-line maintenance treatment setting evaluating rucaparib plus nivolumab (PD-1 inhibitor), rucaparib, nivolumab and placebo in newly-diagnosed patients who have completed platinum-based chemotherapy. 09/17: CLOVIS ONCOLOGY: New Data Presented at ESMO Virtual Congress 2020 Highlight Breadth and Potential of Clovis Oncology Products and Pipeline… The company fell short and the market punished the stock for their shortcoming. This study is part of a broad clinical collaboration with Bristol Myers Squibb. 7.2 Strategic Review of the Pipeline. Earnings fell to a loss of $72.55 million, resulting in a 12.22% decrease from last quarter. At Clovis Oncology, we strive to support patients and caregivers by providing clear, up-to-date, accessible information about our products in development and ongoing clinical trials. CLVS | Complete Clovis Oncology Inc. stock news by MarketWatch. Copyright © 2021 BY CLOVIS ONCOLOGY, ALL RIGHTS RESERVED. Lucitanib clinical development is focused on combinations with checkpoint inhibitors in a variety of solid tumors. and nivolumab in patients with an advanced gynecological solid tumor (Phase 2). For North America, Latin America and Asia Pacific inquires: 1-415-409-7220 1-844-CLVS ONC (1-844-258-7662; U.S. toll-free) Clovis Oncology Announces Exercise by Initial Purchasers of Their Option to Purchase an Additional $13.0 Million Aggregate Principal Amount of the Company’s 4.50% Convertible Senior Notes Due 2024 Download PDF format download (opens in new window) Clovis Oncology presents data on its products in development at a variety of medical conferences. These candidates show the company's promise in the field of oncology, part… Clovis Oncology, Inc., a biopharmaceutical company, focuses on acquiring, developing, and commercializing anti-cancer agents in the United States, the European Union, and internationally. Easily access company info and prior drug data The Company’s peptide-targeted radiopharmaceutical therapy development program includes lead compound FAP-2286 and three additional unnamed preclinical targets discovered by 3B Pharmaceuticals. This study is sponsored by Bristol Myers Squibb. Clovis Oncology, Inc. (NASDAQ:CLVS) today announced its preliminary, unaudited global product revenues for the fourth quarter and full year ended Dece Lucitanib, an investigational angiogenesis inhibitor, which inhibits vascular endothelial growth factor receptors 1 through 3 (VEGFR1-3), platelet-derived growth factor receptors alpha and beta (PDFGRα/β) and fibroblast growth factor receptors 1 through 3 (FGFR1-3). This form is intended for health care professionals licensed in the United States and is for informational purposes only. Eligible patients must have progressed on one prior androgen-receptor targeted therapy and must not have received prior chemotherapy for castration-resistant prostate cancer. New Data Presented at ESMO Virtual Congress 2020 Highlight Breadth and Potential of Clovis Oncology Products and Pipeline jueves, 10 septiembre 2020 yahoo. with Nivolumab and Ipilimumab in Gastric Cancer, A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer (FRACTION-GC). 7.1 Overview. Aktien » Nachrichten » CLOVIS ONCOLOGY AKTIE » Clovis Oncology, Inc.: New Data Presented at ESMO Virtual Congress 2020 Highlight Breadth and Potential of Clovis Oncology Products and Pipeline Please verify that you are a licensed health care professional to find out more about Clovis Oncology Medical Information. Clovis Oncology presents data on rucaparib at a variety of medical conferences. Poster Presentation 2020 SUO Virtual Meeting, Virtual Presentation 2020 PCF Scientific Retreat, Poster Presentation 2020 ESMO Virtual Meeting, Virtual Presentation 2020 ICGS Digital Annual Global Meeting, Poster Presentation 2020 AACR Virtual Meeting II. ... Critical to that pipeline is FAP-2286, and we remain on track both in imaging and the treatment IND for FAP-2286 by the end of this year. A Phase 1/2, Multicenter, Open-label, Non-randomized Study to Investigate Safety and Tolerability, Pharmacokinetics, Dosimetry, and Preliminary Activity of 177LuFAP-2286 in Patients with an Advanced Solid Tumor, A Phase 3 Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy. Exploratory studies in other tumor types are also underway. The company offers Rubraca (rucaparib), an oral small molecule inhibitor of poly ADP-ribose polymerase for recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. Randomized open-label Phase 3 study evaluating the effects of rucaparib compared to physician’s choice of therapy for patients with metastatic castration-resistant prostate cancer (mCRPC) with specific gene alterations including BRCA and ATM (both inclusive of germline and somatic). At this time, all participants are in a listen-only mode. The primary endpoint of the study is progression-free survival. Clovis has global rights for lucitanib excluding China. Pipeline Assessment . This drug is an angiogenesis inhibitor -- meaning it stops blood vessels from being formed -- and it's being used in combination with Rubraca for treating advanced ovarian cancer. Clovis Oncology recently reported their Q3 earnings with a beat on EPS and a miss on revenue. A multi-arm Phase 2 study evaluating the combinations of each of rucaparib with nivolumab and ipilimumab as well as rucaparib, nivolumab and ipilimumab in combination for the treatment of advanced gastric cancer. The ODAC reviews and evaluates data related to the safety and effectiveness of marketed and investigational human drug… For more information on how we use cookies, please see our Cookie Policy and Privacy Policy. ATHENA (A Multicenter, Randomized, Double-Blind, Placebo- Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy). CLOVIS ONCOLOGY: New Data Presented at ESMO Virtual Congress 2020 Highlight Breadth and Potential of Clovis Oncology Products and Pipeline: AQ. A Phase 2 Investigational immunotherapy study of nivolumab in combination with rucaparib, docetaxel, or enzalutamide in metastatic castration-resistance prostate cancer (mCRPC). Rucaparib in Patients with Solid Tumors and with Deleterious Mutations in Homologous Recombination Repair (HRR) Genes (LODESTAR), A Phase 2, open-label, single-arm trial to evaluate the response of rucaparib in patients with various solid tumors and with deleterious mutations in homologous recombination repair (HRR) genes, with Sacituzumab Govitecan in Multiple Tumor Types, SEASTAR: A Phase 1b/2, Open-label, Parallel Arm Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Oral Rucaparib in Combination With Other Anticancer Agents in Patients With a Solid Tumor, A Phase 1b/2 study of rucaparib and sacituzumab govitecan, an antibody drug conjugate, for the treatment of advanced metastatic triple-negative breast cancer, relapsed platinum-resistant ovarian cancer and advanced metastatic urothelial cancers, A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor. FAP-2286 is an unlicensed medical product. Confirmatory Phase 3 multicenter, randomized study of rucaparib versus chemotherapy in relapsed ovarian cancer patients with BRCA mutations who have failed two prior lines of therapy. Phase 1b/2, open-label study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of lucitanib and nivolumab in patients with an advanced gynecological solid tumor (Phase 2). CLVS Weekly Chart CLVS Daily Chart Clovis Oncology, Inc. (CLVS) has a new drug application (NDA) for its lead pipeline candidate, Rociletinib, scheduled to be reviewed by the FDA’s Oncologic Drugs Advisory Committee (ODAC) on Apr 12, 2016. Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Make no doubt, Clovis is a powerful turnaround growth stock. Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Clovis Oncology, Inc. today announced the data being presented as e-posters at the European Society for Medical Oncology Virtual Congress 2020. Rucaparib, an oral, small molecule inhibitor of poly (ADP-ribose) polymerase (PARP)1, 2 and 3 is being developed in multiple tumor types, including ovarian and prostate cancers, as monotherapy and in combination with other anti-cancer agents. The company is a publicly traded company on NASDAQ under the symbol "CLVS" and is in the NASDAQ Biotechnology Index with several products in its product pipeline. Rubraca records sales of $38.8 million despite sales challenges . Clovis has several candidates in its pipeline including its promising compound lucitanib. 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Information on how we use cookies, please see our cookie Policy and Privacy Policy antiangiogenic drugs may reverse immunosuppression. The nivolumab + rucaparib combination in mCRPC is being tested in combination with Either rucaparib Docetaxel. A different clovis compound called rucaparib is being conducted as an arm of a larger Myers... Not have received prior chemotherapy for castration-resistant prostate Cancer to Test combination Treatments in patients with an gynecological! Of antiangiogenic drugs may reverse this immunosuppression and augment response to immunotherapy, you agree to our use cookies. You for standing by, and welcome to the clovis Oncology Inc. stock news by MarketWatch excluding Europe % from!
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