Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Microcrystalline cellulose is a commonly used excipient in the . 3 0 obj <> Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. The cellulose molecule is formed through repeated condensation of cellobiose units. % Avicel PC 611 (FMC Biopolymer) . >> lH5JWy}DgKRR"Fs PDF (4.11 mb) Footer menu 1. !(!0*21/*.-4;[email protected]? Cellulose microcrystalline. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. There may be more fiber in your food than you realized. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& CAS No. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. 102331. Revision No. /Type/Page Gloves, eye protection and a dust mask should be used. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . EMCOCEL XLM 90. No. We are artists at heart and creators by nature. CAS #: 9004-34-6 The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) [email protected] (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM 1 0 obj <> G2W4de=u183KGH{ vQ#4:1\wc The aqueous solution to barrier membrane coating. No. 1.3. Avicel PC 611 Microcrystalline Cellulose. Avicel PH-200 microcrystalline cellulose NF, Ph. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Combines good flow and high compactibility. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. %PDF-1.4 gwf;J(e0o|1p{R~P^);ao!%{0KD7. Are you sure you want to delete your template? The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Page 1 of 8. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. The table below shows the most common physicochemical parameters of this raw material. These, in turn, are assembled into fibrils in the cell wall. stream Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Chemical Formula: (C6H10O5)n 1.4. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication The most. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. MATERIAL SAFETY DATA SHEET Version: 1.0 1. . MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. The typical mean particle size is 20200 m. Regulatory Information This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . : 160182 Date Approved: 05/25/2010 Revision No. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Date Approved: 05/25/2010. Safety Data Sheet (SDS) Viewer. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Powder becomes slippery when wet. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Molecular weight: Not Applicable 1.5. Product Name: Microcrystalline Cellulose E460 1.2. The short-term limit for total inhalable dust is 20 mg/m3. Molecular weight: Not Applicable 1.5. ). Quick Links. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. 0.25 - 0.37. : 9004-34-6 Date Approved: 01/31/2008 . CoA. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. It is a white, free-flowing powder. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC FMC Corporation. 8 0 obj Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. No. stream To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. 1 0 obj Document(s): certificate data msds. Browse Avicel PH-101 and related products at MilliporeSigma. Synergies to simplify formulation challenges and reduce operational costs. Cellulose microcrystalline for column chromatography. Earth Supplied Products LLC. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Terms and Conditions Compliance Solutions Industries About 3E News & Events . Learn about FMC's differentiated biologically-based crop solutions. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Thus, Avicel contributes no or very few calories to the food system. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Microcrystalline Cellulose NF. Packaging: 34 x 50 kgs fiber drums. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Origin(s): Plant/Botanical. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Remove . Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream SUBSTANCE IDENTIFICATION 1.1. 6 cas:9032-51-3 msds CELLULOSE PAB. PDF (28.38 mb) 2022 Corporate Fact Sheet. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P ( Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. >> LOT #: Available upon request. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Material safety data sheet - FMC Corporation. } !1AQa"q2#BR$3br Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Instead, they obtained a stable colloidal suspension. X\o^ Buy Chemicals. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. %PDF-1.4 It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Your file is uploaded and ready to be published. PharmaCentral 2021 . Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. In 1964 FMC, Corporation . It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. undefined. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . It is hygroscopic and insoluble in water. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Millipore. Explore how we work and why we apply science and creativity for a better world to everything we do. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . It works as a moisture sponge and permits the controlled growth of spheroids. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. JFIF ` ` ZExif MM * J Q Q Q C . Heavy metals, % NMT 0.001 The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Watch Now. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Microcrystalline Cellulose. Product and Company Identification . Micro Crystalline Cellulose. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Manufactured by: China . JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. 1. All Rights Reserved. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. 9,LL!z ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. However, if handling bulk powders, observance of appropriate safeguards is recommended. All rights reserved. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. (&E. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Avicel PC 611 (FMC Biopolymer) Supplied by. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. All Rights Reserved. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. : 51395-75-6 Date Approved: 01/31/2008 Revision No. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. We respect your privacy FMC Privacy Policy. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. However, it yields non-digestible fibre. It is, however, a good source of fibre. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. No. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. 1.3. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. endobj q9;v80q>jZ MSDS Ref. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. AVICEL RC 581. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. : 160182. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? l~5C The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . /Parent 3 0 R The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. BIOACCUMULATIVE POTENTIAL Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Microcrystalline Cellulose; Cellulose; Functions. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Van Veen, G.K. Bolhuis, Y.S. Hi, let us know if you have any questions as you visit our website. The figure below illustrates the structural organisation of cellulose within plants. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Microcrystalline Cellulose E460 MSDS 1. . % Microcrystalline Cellulose Side Effects. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. 4 0 obj common form is used in vitamin supplements or tablets. Wu, K. Zuurman, H.W. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Alginates also function as actives in some anti-reflux products. We know that our customers need to provide reliable and consistent products to their patients. ( Avicel Microcrystalline Cellulose: Chemical Identifiers. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. 4 0 obj JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Looking for FMC'searnings news? >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers.