WebNeurogenesis was found to be reversed to normal 35 days after the last finasteride injection in male mice. Long term HCG treatment at high dosages can cause issues. I read about the Post-Fin Syndrome and decided to quit (Almost) No erections, no libido. This is a summary of the protocol which I followed for 6 months which eventually cured me. I will tell you how I solved my problem with post-finasteride syndrome, which produces no erections or little libido even if you have stopped taking the famous drug years ago. Drugs to treat retrograde ejaculation are drugs primarily used to treat other conditions, including: Imipramine, an antidepressant. Personally, I believe its become the boogeyman for a bucket list of sexual problems. If you have retrograde ejaculation, you'll likely need treatment to get your female partner pregnant. Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Rev Endocr Metab Disord. Ejaculation and orgasm disorders. After taking 50mg of Proviron I got my first erection in years. Since it only comes in 5 and 1 mg pills, there isnt much of a choice. Drugs to treat retrograde ejaculation are drugs primarily used to treat other conditions, including: These medications help keep the bladder neck muscle closed during ejaculation. Psychopharmacology (Berlin) 2014;231:35693580. 2022 Apr;181:157-166. doi: 10.1016/j.brainresbull.2022.01.020. Epub 2010 Dec 22. Make a donation. For details, see text. "I had a case of PFS that was a severe as it gets. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. What Causes Hair Loss in Women? Accessed Sept. 15, 2016. When dosed properly, it can bring DHT within normal ranges very effectively. Samplaski MK, et al. government site. In addition, it has been also reported that persistent side effects may occur in some AGA patients. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. As here reported, these observations are mainly based on self-reporting of the symptomatology by the patients and few clinical studies have been performed so far. I took a large amount of DHT (proviron) for 7 weeks at 200 mg per day to reduce receptor sensitivity to DHT. I was one of the lucky guys who recovered from Test injections, https://old.reddit.com/r/steroids/comments/igyd61/offtopic_daily_chat_20200826/g2ym80n/. These include: Prostate pain Persistent fatigue, exhaustion Stomach pains and digestive problems Constipation Blurry vision Propecia is the Biggest Regret of my Life Taking Propecia is the biggest regret of my life, PK said. However, minoxidil is used "off-label" for treating telogen effluvium, scarring alopecia and alopecia areata. Getting to the root cause of your hairloss would be the first thing to do as if you have an underlying medical condition, once thats treated, it could reverse the hairloss, so definately get a consultation with a physician to rule out anything treatable. In addition, molecular mechanisms and/or genetic determinants behind such adverse effects have been poorly explored both in patients and animal models. WebHow to Correct Post Finasteride Syndrome Minimize Stressors. This report will provide you with the information you need to understand the current controversies, avoid common pitfalls, and work with your doctor to make informed choices about your prostate health. In this review, we focused our attention on adverse events related to 5 alpha-reductase (5-R) inhibitors (i.e., finasteride and dutasteride), approved for the treatment of benign prostatic hyperplasia and androgenetic alopecia (AGA). Maybe if theyre lucky in 10 years. At higher doses, finasteride (Proscar) can also treat benign prostatic hyperplasia (BPH). As a 5-alpha reductase inhibitor, finasteride works by inhibiting the effects of the enzyme thats responsible for converting testosterone into dihydrotestosterone (DHT). Keywords: No interest in sex at all. I had a case of PFS that was a severe as it gets. Ohl DA, et al. Accessed Oct. 28, 2021. Im glad I did. WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or Minoxidil takes 4-6 months before an individual should assess whether or not it helps. Your doctor will want to determine whether your dry orgasms are retrograde ejaculation or linked to another problem that may need further evaluation. Gained 25 pounds of mostly muscle. Metabolism of progesterone and testosterone, Metabolism of progesterone and testosterone into 5alpha-reduced metabolites and their mechanisms of action:, Clinical features reported in patients affected by post-finasteride syndrome. (photo). Int. Its on an auto refill and I get 90 day supplies sent to me in the mail. Disclaimer. ._12xlue8dQ1odPw1J81FIGQ{display:inline-block;vertical-align:middle} What is likely causing my symptoms or condition? Fertility and Sterility. Lol, now they banned me, just look at the reason: Dismissive of survey in first few posts; insistently advocated for dangerous and misleading article on PFS. Health Alerts from Harvard Medical School. No active 34 year old man should have to be having ED discussions with his physician. https://www.amazon.com/reviews/R3OGTPUQ1CP005. If your doctor thinks drugs you are taking might be affecting your ability to ejaculate normally, he or she might have you stop taking them for a period of time. Feeling dissociated and never present. I had all the classic symptoms. Tamoxifen I did 20mg during the four weeks every day. It can prevent hair loss and decrease prostate enlargement, but not surprisingly, it can also suppress sexual function. Write down any symptoms you're experiencing, including any that might seem unrelated to the reason for which you scheduled the appointment. I took intramuscular injections of HCG every 3 a 5 days 1500 to 3000 ui by injections for 1 months only, and after that some Clomid for 10 days 2 pills by day It helped relaunch the natural testorene levels so my libido increased again i am now totally satisfied with my health :slight_smile: https://forum.propeciahelp.com/t/i-believe-i-have-been-cured-by-accident/4054, Yes After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome, All my symptoms have subsided and improved with this method which takes a while but I am fully functional. https://old.reddit.com/r/steroids/comments/m5m7o9/help_steroids_for_pssd/gr0uhqj/. Next steps is likely getting a Hey there, If your doctor suspects your dry orgasm is something other than retrograde ejaculation, you might need further tests or a referral to a specialist to find the cause. Ran [Tbol] 250mg for 2 months increased the dosages anywhere from 500mg to 1000mg. The number of men sharing their experience of Post-Finasteride Syndrome is steadily rising, painting a bleak picture of the life-shattering effects the drug can have. | How To Diagnose And Reverse It. HHS Vulnerability Disclosure, Help Mod also deleted my second post where I said he indeed has affiliate links to herbs but doesnt even believe that will be enough for pfs patients, the real cure is proviron, of course he doesnt have any affliate links to those products. You're likely to start by seeing your family doctor. 12th ed. All rights reserved. Nature Reviews Urology. I has numbness also. I recovered and I hope all of you suffering from PFS recover too. I dont really understand why theyre like that. After stopping 7 weeks later (when I ran out of my proviron), things felt off for a few weeks but then after around two months I got back to my pre-PFS state. Chlorpheniramine and brompheniramine, antihistamines that help relieve allergies. reading time: 43 Note that prior to this protocol I tried injectable Test enanthate, Masteron, proviron and hcg which made my condition even worse. Talking with a counselor might help. Why not save the other half for your next dose? WebPost finasteride syndrome is real. Proton-pump inhibitors: Should I still be taking this medication? While we do connect people with vetted, board-certified doctors, we dont provide medical consultations, diagnosis, or advice. I think it took 6 months before i felt ready to meet a girl again. Can sperm be retrieved from my bladder and used for fertility treatment? Now I can happily say that I no longer have any problem, strong erection all day and all night. It is available as a generic. If medication doesn't allow you to ejaculate semen, you will likely need infertility procedures known as assisted reproductive technology to get your partner pregnant. So yes, it is not Dermatologic Surgeon, Board Certified in Dermatology, How Long Does Minoxidil 5 Take to Work? Examples include bladder neck surgery and transurethral resection of the prostate. On PFS forums, peoples dicks got 1 inch bigger when erect, here and there, they sometimes felt sexual attraction towards women. I'll be interested to see if this has any effects on my weight loss endeavors. Feeling low-grade depression constantly. Li X, Guo Y, Lu Y, Li H, Yan S, Li H, Li Y. Transl Androl Urol. This procedure is usually done at the doctor's office. I dunno, I dont get it. Plentiful in opinions, short on facts. And yeah I know hackstasis, looks to be a much better community and forum than propeciahelp without fascist mods. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. BONUS! Yeah, yeah. http://www.resolve.org/about-infertility/what-is-infertility/frequently-asked-questions-about-infertility.html. That is 250IU, not a typo so youll mix your 5000iu HCG with 5CC water and take 1/4 CC intramuscular three times a week using an insulin needle Have you heard about it? Of course there are some people with severe pfs but even then just wait is shit advice. Biomolecules. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Im talking about the physical inability to have erections and sex drive". I need to get back over there and check it out I guess. Hcg I did 3000iu the first day then 250iu every other day for the four weeks. 2011 Mar;8(3):872-84. doi: 10.1111/j.1743-6109.2010.02157.x. .c_dVyWK3BXRxSN3ULLJ_t{border-radius:4px 4px 0 0;height:34px;left:0;position:absolute;right:0;top:0}._1OQL3FCA9BfgI57ghHHgV3{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;-ms-flex-pack:start;justify-content:flex-start;margin-top:32px}._1OQL3FCA9BfgI57ghHHgV3 ._33jgwegeMTJ-FJaaHMeOjV{border-radius:9001px;height:32px;width:32px}._1OQL3FCA9BfgI57ghHHgV3 ._1wQQNkVR4qNpQCzA19X4B6{height:16px;margin-left:8px;width:200px}._39IvqNe6cqNVXcMFxFWFxx{display:-ms-flexbox;display:flex;margin:12px 0}._39IvqNe6cqNVXcMFxFWFxx ._29TSdL_ZMpyzfQ_bfdcBSc{-ms-flex:1;flex:1}._39IvqNe6cqNVXcMFxFWFxx .JEV9fXVlt_7DgH-zLepBH{height:18px;width:50px}._39IvqNe6cqNVXcMFxFWFxx ._3YCOmnWpGeRBW_Psd5WMPR{height:12px;margin-top:4px;width:60px}._2iO5zt81CSiYhWRF9WylyN{height:18px;margin-bottom:4px}._2iO5zt81CSiYhWRF9WylyN._2E9u5XvlGwlpnzki78vasG{width:230px}._2iO5zt81CSiYhWRF9WylyN.fDElwzn43eJToKzSCkejE{width:100%}._2iO5zt81CSiYhWRF9WylyN._2kNB7LAYYqYdyS85f8pqfi{width:250px}._2iO5zt81CSiYhWRF9WylyN._1XmngqAPKZO_1lDBwcQrR7{width:120px}._3XbVvl-zJDbcDeEdSgxV4_{border-radius:4px;height:32px;margin-top:16px;width:100%}._2hgXdc8jVQaXYAXvnqEyED{animation:_3XkHjK4wMgxtjzC1TvoXrb 1.5s ease infinite;background:linear-gradient(90deg,var(--newCommunityTheme-field),var(--newCommunityTheme-inactive),var(--newCommunityTheme-field));background-size:200%}._1KWSZXqSM_BLhBzkPyJFGR{background-color:var(--newCommunityTheme-widgetColors-sidebarWidgetBackgroundColor);border-radius:4px;padding:12px;position:relative;width:auto} An official website of the United States government. I took a step back and said forget about PFS with these blood tests and these symptoms, whats the normal course of action? Crazy, but true! ._1QwShihKKlyRXyQSlqYaWW{height:16px;width:16px;vertical-align:bottom}._2X6EB3ZhEeXCh1eIVA64XM{margin-left:3px}._1jNPl3YUk6zbpLWdjaJT1r{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;display:inline-block;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;padding:0 4px}._1jNPl3YUk6zbpLWdjaJT1r._39BEcWjOlYi1QGcJil6-yl{padding:0}._2hSecp_zkPm_s5ddV2htoj{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;display:inline-block;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;margin-left:0;padding:0 4px}._2hSecp_zkPm_s5ddV2htoj._39BEcWjOlYi1QGcJil6-yl{padding:0}._1wzhGvvafQFOWAyA157okr{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;box-sizing:border-box;line-height:14px;padding:0 4px}._3BPVpMSn5b1vb1yTQuqCRH,._1wzhGvvafQFOWAyA157okr{display:inline-block;height:16px}._3BPVpMSn5b1vb1yTQuqCRH{background-color:var(--newRedditTheme-body);border-radius:50%;margin-left:5px;text-align:center;width:16px}._2cvySYWkqJfynvXFOpNc5L{height:10px;width:10px}.aJrgrewN9C8x1Fusdx4hh{padding:2px 8px}._1wj6zoMi6hRP5YhJ8nXWXE{font-size:14px;padding:7px 12px}._2VqfzH0dZ9dIl3XWNxs42y{border-radius:20px}._2VqfzH0dZ9dIl3XWNxs42y:hover{opacity:.85}._2VqfzH0dZ9dIl3XWNxs42y:active{transform:scale(.95)} Its easy to point to a little blue pill you took 10 years ago than to look for other causes. I understand not wanting to have a bunch of hack cures on their forum that dont really do anything or worse yet, make people worse, but at some point when theres a condition we dont know how to fix it seems like some trial and error wouldnt be the worst idea in the world. Key takeaways: Finasteride is an FDA-approved medication that treats hair loss in men. i am so desperate.. i am a female.. i need my hair back.. but o reallu cannot undergoo all this syntomps ( i gained 20 kg on fina and dutasterde.. no muscle stranght anymore.. no way to lose weight.. i really can' t tell a lot about mental and neurological condition.. but II am so depressed too.. but probably because I am bald and fat there must be a way to take fina without sides.. there must be a way..). Side effects of treatment with 5 alpha-reductase inhibitors in experimental models. -, Basaria S., Jasuja R., Huang G., Wharton W., Pan H., Pencina K., Li Z., Travison T.G., Bhawan J., Gonthier R., Labrie F., Dury A.Y., Serra C., Papazian A., O'Leary M., Amr S., Storer T.W., Stern E., Bhasin S. Characteristics of men who report persistent sexual symptoms after finasteride use for hair loss. Now and for the past six months, I feel great, my libido is great, mental issues are gone, ED is gone. 2022 Oct 26;12(11):1567. doi: 10.3390/biom12111567. A single copy of these materials may be reprinted for noncommercial personal use only. When did you first begin having dry orgasms? Your doctor will ask you questions about your health and symptoms. Is Post Finasteride Syndrome Real? I suspect that 2 mg would be adequate, but if my doc prescribes two 1mg pills per day, the insurance company wont pay for it because the 1mg pill is only approved for hair loss treatment. I am 100% reversed Keep in mind if I miss a dose or stop my protocol Pfs comes back full force. PDF | Finasteride was patented in 1984 and approved for medical use in 1992. I'm not going to go into the entire history of what post finasteride syndrome is, and I assume many of you looking into buying Tribulus know exactly what it is. After a bit over a week I decreased the dose to 10mg before bedtime and none in the afternoon. The presence of side effects during pharmacological treatment is unfortunately a quite common problem. Get the latest in health news delivered to your inbox! sharing sensitive information, make sure youre on a federal Therefore, I cut the pills in half (2.5mg) and toss the other half. 150mg/ day transdermal Testosterone gel applied to scrotum - 50mg/ day DHT gel applied to inner forearms and penis - 50mg oral pregnenolone/25mg DHEA daily, https://old.reddit.com/r/FinasterideSyndrome/comments/u1svwo/has_anyone_else_recovered_from_watery_semen_and/i4eg1it/?context=999. If so, how long have you been trying to conceive? If a high volume of sperm is found in your urine, you have retrograde ejaculation. Stop watching porn, stop masturbating, forget about sex, meditate, take cold showers, try breathing exercises, try extended water fasting. I only said everyone should read it, especially in light of the big new proviron recovery on the forum there. Most men eventually develop some type of prostate problem, and when they do there are usually no easy solutions. The mods on that forum are fascists and dont allow the opinion and theory of other people. Crazy. Understanding all of your options and communicating with your doctor and partner can help. Effect of 5-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials. 2016;93:9. After 4 months of no progress whatsoever I tried the regimen that saved me - at least thats the only explanation I have. Est. Your doctor might also do a physical exam that includes examining your penis, testicles and rectum. Do they benefit from people who have pfs so their foundation can continue and ask for more donations? Will my partner and I likely need to use assisted reproductive technology, such as intrauterine insemination, to achieve pregnancy? https://www.jasonemermd.com/cosmetic-dermatology/regenerative-medicine/hormonal-optimization/. Metabolism of progesterone and testosterone into 5alpha-reduced metabolites and their mechanisms of action: effects of finasteride and dutasteride. -. Hello, some finasteride users have reported the reversal of post-finasteride syndrome using HCG as therapy. Therefore, I cut the pills in half (2.5mg) and toss the other half. I have the desire for sex and intimacy but my brain simply wont communicate with my penis when its time for intercourse. To give you a bit of background, I'm a 34 year old male whose sexual function was utterly destroyed by finasteride/Propecia. Urology. Don't miss your FREE gift. Disorders of male orgasm and ejaculation. Would you like email updates of new search results? I do not think we have an answer to that question one way or the other. Alterations in orgasm are linked with lower emotional and physical satisfaction, which might lead to stress for you and your partner. In this review, we focused our attention on adverse events related to 5 alpha-reductase (5-R) inhibitors (i.e., finasteride and dutasteride), approved for the treatment of benign prostatic hyperplasia and androgenetic alopecia (AGA). The only thing that makes sense is to push your androgen receptors and epigenetics the opposite way fin did. I also started a thread but they merged it. It can cause bladder and urination problems. Took finasteride for 5 months. I feel like I have my life back. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. Very controversial topic in this forum. @keyframes _1tIZttmhLdrIGrB-6VvZcT{0%{opacity:0}to{opacity:1}}._3uK2I0hi3JFTKnMUFHD2Pd,.HQ2VJViRjokXpRbJzPvvc{--infoTextTooltip-overflow-left:0px;font-size:12px;font-weight:500;line-height:16px;padding:3px 9px;position:absolute;border-radius:4px;margin-top:-6px;background:#000;color:#fff;animation:_1tIZttmhLdrIGrB-6VvZcT .5s step-end;z-index:100;white-space:pre-wrap}._3uK2I0hi3JFTKnMUFHD2Pd:after,.HQ2VJViRjokXpRbJzPvvc:after{content:"";position:absolute;top:100%;left:calc(50% - 4px - var(--infoTextTooltip-overflow-left));width:0;height:0;border-top:3px solid #000;border-left:4px solid transparent;border-right:4px solid transparent}._3uK2I0hi3JFTKnMUFHD2Pd{margin-top:6px}._3uK2I0hi3JFTKnMUFHD2Pd:after{border-bottom:3px solid #000;border-top:none;bottom:100%;top:auto} Day 1 I felt no difference. I'll never be without this stuff again. there are many options including peptides, and HCG as well as clomid/arimidex. In: Ferri's Clinical Advisor 2022. https://old.reddit.com/r/FinasterideSyndrome/comments/psjeuu/could_trying_finasteride_for_1_month_be_harmfull/he38hlf/. doi: 10.1016/j.urology.2018.06.022. When you are on TRT, your DHT levels tend to go out of the normal range and finasteride is a mechanism for bringing it back into range. Ive seen this several times over there. Archivio Istituzionale della Ricerca Unimi, NCI CPTC Antibody Characterization Program, Agis-Balboa R.C., Guidotti A., Pinna G. 5alpha-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. Amedical opinion on this procedure would be important, because we do not have scientific evidence about HCG and PFS, but it would already be a start. Res. And youre competely right, they make it sound like youre doomed and you shouldnt try anything but wait for the Baylor study and fill out the surveyDo they really expect some magical cure to come out when Baylor releases or their survey has enough participants? My personal experience is that finasteride is an important medication for older guys on TRT that are experiencing BPH. ._2ik4YxCeEmPotQkDrf9tT5{width:100%}._1DR1r7cWVoK2RVj_pKKyPF,._2ik4YxCeEmPotQkDrf9tT5{display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center}._1DR1r7cWVoK2RVj_pKKyPF{-ms-flex-pack:center;justify-content:center;max-width:100%}._1CVe5UNoFFPNZQdcj1E7qb{-ms-flex-negative:0;flex-shrink:0;margin-right:4px}._2UOVKq8AASb4UjcU1wrCil{height:28px;width:28px;margin-top:6px}.FB0XngPKpgt3Ui354TbYQ{display:-ms-flexbox;display:flex;-ms-flex-align:start;align-items:flex-start;-ms-flex-direction:column;flex-direction:column;margin-left:8px;min-width:0}._3tIyrJzJQoNhuwDSYG5PGy{display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center;width:100%}.TIveY2GD5UQpMI7hBO69I{font-size:12px;font-weight:500;line-height:16px;color:var(--newRedditTheme-titleText);white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.e9ybGKB-qvCqbOOAHfFpF{display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center;width:100%;max-width:100%;margin-top:2px}.y3jF8D--GYQUXbjpSOL5.y3jF8D--GYQUXbjpSOL5{font-weight:400;box-sizing:border-box}._28u73JpPTG4y_Vu5Qute7n{margin-left:4px} For details, see text., Side effects of treatment with 5 alpha-reductase inhibitors in experimental models. I haven't introduced any other supplements or medications. J. Clin. Speaking of which the proviron I ordered over a year ago randomly came in the mail the other day, haha. If we cant discuss potential cures then that forum is completely worthless and I start to doubt their real intentions. Are there any brochures or other printed material that I can take home with me? Are there other possible causes for my symptoms or condition? The presence of side effects during pharmacological treatment is unfortunately a quite common problem. Post-finasteride syndrome: a surmountable challenge for clinicians.