Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. However, the potential molecular mechanism is still unknown. Nature Communications. 2-4 DNP uncouples respiration from ATP synthesis, stimulating both respiration and glycolysis. The alternative cancer world has long seen this fact as a therapeutic strategy to help block cancer’s fuel source. The theoretical evolutionary game theory supports the idea that cells with a higher rate, but lower yield, of ATP production may gain a selective advantage when competing for shared and limited energy resources [xii] [xiii] . Like glycolysis, lipogenesis is enhanced in cancer cells compared to normal cells, and both pathways are linked. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no exception. 2004;64(3):985–993. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. CPNE1 Enhances Colorectal Cancer Cell Growth, Glycolysis, and Drug Resistance Through Regulating the AKT-GLUT1/HK2 Pathway Javascript is currently disabled in your browser. MicroPET/CT demonstrated that ketamine decreased 18F‐FDG uptake in the xenograft model. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer patients. Copyright © 2019 The Authors. Although glycolysis is substantially elevated in many tumors, therapeutic targeting of glycolysis in cancer patients has not yet been successful, potentially reflecting the metabolic plasticity of tumor cells. Glycolysis is a universal pathway in the living cells. In 1930, Warburg hypothesized that cancer was caused by the acid-producing breakdown of glucose during a process called glycolysis. Potential of Taming MicroRNA on Driver Seat to Control Mitochondrial Horses in Breast Carcinoma. Production and hosting by Elsevier B.V. https://doi.org/10.1016/j.jons.2017.06.002. It is therefore, imperative for cancer cells to devise strategies to ensure the constant supply of these precursors, and this it achieves through aerobic glycolysis. 2020 Sep 15;202:112603. doi: 10.1016/j.ejmech.2020.112603. Background: Cancer cells possess a common metabolic phenotype, rewiring their metabolic pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic circuits, to support the energetic and biosynthetic requirements of continuous proliferation and migration. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not. Tumor hypoxia microenvironment cause hypoxia-inducible factors (HIFs) containing HIF-1α … Cancer cells face the challenges of how to provide the requisite bioenergy and biosynthetic precursors to meet up with the ever-increasing genome and biomass. Serguienko A, Grad I, Wennerstrøm AB, Meza-Zepeda LA, Thiede B, Stratford EW, Myklebost O, Munthe E. Oncotarget. to produce energy for cell function and replication. This site needs JavaScript to work properly. Background. Citation Format: Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Raquel Buj, Katherine M. Aird. Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA. 1956;124(3215):269–270. Inhibition of glycolysis has been considered as a therapeutic approach in aggressive cancers including lung cancer. Adv Exp Med Biol. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumor microenvironment. 2012 Aug;12(4):285-91. doi: 10.2174/156652312802083620. and glycolysis in the A549 human cancer cell line. Tilekar K, Upadhyay N, Hess JD, Macias LH, Mrowka P, Aguilera RJ, Meyer-Almes FJ, Iancu CV, Choe JY, Ramaa CS. Glucose metabolism in cancer cells is primarily characterized by two major biochemical events: (i) increased glucose uptake and (ii) aerobic glycolysis, the process of conversion of glucose into pyruvate eventually resulting in the production of lactate (fermentation). Clipboard, Search History, and several other advanced features are temporarily unavailable. 2012 Nov 13;22(5):565-6. Sigma-Aldrich presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Lu C, Zhou D, Wang Q, Liu W, Yu F, Wu F, Chen C. Oxid Med Cell Longev. Over 70 years ago, Warburg (1) observed that cancer cells frequently exhibit increased glycolysis and... Materials and … The purpose of this study was to identify glycolysis-related genes of prognostic value in HNSCC. HHS He found that, even in the presence of ample oxygen, cancer cells prefer to metabolize glucose by glycolysis, a seeming paradox as glycolysis, when compared to oxidative phosphorylation, is a less efficient pathway for producing ATP (Warburg, 1956 Comment in Cancer Cell. In contrast, the suppression of cancer cell progression and glycolysis could be reversed by overexpressing IGF2BP2, especially by the K139R mutant without the LINRIS-binding site. Hypothesis. 2015;888:123-54. doi: 10.1007/978-3-319-22671-2_8. Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Cancer cells in this model only help each other if enough of them use glycolysis, all producing toxic lactic acid to kill healthy cells and make more room in the environment to grow. This phenomenon is observed even in the presence of completely functioning mitochondria and, together, is known as the ‘Warburg Effect’. Epub 2020 Jul 2. Science. Cancer cells and stem cells also use glycolysis as the main source of ATP (process known as aerobic glycolysis, or Warburg effect). Chin J Cancer. Tumor cells are characterized by abnormal glycolysis, accompanied by increased glucose uptake and lactate production, which is called aerobic glycolysis or Warburg effect [ 1 ]. This adaptation favours cancer cells not only for energy production but also for formation of phospholipid bilayers, and protection against oxidative damage and stress induced cell … Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. This reliance on aerobic glycolysis is called the Warburg effect, and promotes tumorigenesis and malignancy progression. High glycolysis is associated with poor prognosis in patients with colorectal cancer (CRC). Aims . Scope of review: While, over the past decade, molecular and cellular studies have clearly highlighted the association of oncogenes and … Glycolysis is the metabolic pathway that converts glucose C 6 H 12 O 6, into pyruvate, CH 3 COCOO − (pyruvic acid), and a hydrogen ion, H +.The free energy released in this process is used to form the high-energy molecules ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide). 1 With the progress of medical technology in recent years, the diagnosis and treatment of BC have been greatly improved. Seven glycolysis-related gene sets were selected from MSigDB and were analyzed through GSEA. Major conclusions: ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. 2020 May 16;20:171. doi: 10.1186/s12935-020-01256-1. Cancer is a disease at the cellular level involving heritable disorders in cellular control mechanism. ATM inhibitor synergizes with glycolysis inhibition in ovarian cancer cells [abstract]. Ketamine treatment inhibited colon cancer cell viability and migration in HT29 and SW480 cells. We highlighted the various suggested novel anti-cancer therapeutic targets in these metabolic pathways. However, the prognostic significance of glycolysis-related genes in head and neck squamous cell carcinoma (HNSCC) remains obscure. Since proliferation of cancer tissues is faster than normal tissues, it not only needs energy, but also needs metabolic intermediates for the biosynthesis of macromolecules. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Matsuo T, Konya Y, Hirayama E, Sadzuka Y. Oncol Lett. At this point, serum pH is reduced which can lead to organ dysfunction if severe and untreated. Moreover, cancer cells invariably choose the ancient metabolic pathway—glycolysis—to produce energy. -, Rossignol R., Gilkerson R., Aggeler R., Yamagata K., Remington S.J., Capaldi R.A. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. This means that cancer cells derive most of their energy from glycolysis that is glucose is converted to lactate for energy followed by lactate fermentation, even when oxygen is available. Understanding the nuanced regulation of gene expression in these cells and distinguishing rapid cellular responses from chronic adaptive mechanisms provides a basis for rational drug design and novel therapeutic strategies. Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia Introduction. Breast cancer (BC) is a prevalent malignant tumor among women, whose incidence is gradually increasing in recent years with the changes of social environment and living habits. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Breast cancer continues to be the second leading cause of cancer-associated … Science. Background: A metabolic circuit in T cell immunity. However, the potential correlation between the gut microbiota and … Like glycolysis, lipogenesis is enhanced in cancer cells compared to normal cells, and both pathways are linked. As a young scientist in the 1920s, Otto Heinrich Warburg described an elevated rate of glycolysis occurring in cancer cells, even in the presence of atmospheric oxygen (the Warburg effect) that earned him a Nobel Prize. Liu J, Liu H, Zeng Q, Xu P, Liu M, Yang N. Cancer Cell Int. Glycolysis is a central metabolic pathway for tumor cells. Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN. The Emerging Role of MitomiRs in the Pathophysiology of Human Disease. CPNE1 Enhances Colorectal Cancer Cell Growth, Glycolysis, and Drug Resistance Through Regulating the AKT-GLUT1/HK2 Pathway Javascript is currently disabled in your browser. Birts et al. 2020 Apr 28;2020:2415324. doi: 10.1155/2020/2415324. Hypothesis. Cancer cells possess a common metabolic phenotype, rewiring their metabolic pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic circuits, to support the energetic and biosynthetic requirements of continuous proliferation and migration. Excessive anaerobic glycolysis produces large quantities of lactic acid. -, Zhang H., Wang Y., Xu T., Li C., Wu J., He Q. See this image and copyright information in PMC. Cancer cells turn on aerobic glycolysis so they could grow more rapidly and compete for energy. Constitutive activity of the serine/threonine kinase Akt is a … Although the ATP produced by tumor glycolysis is not much, it can supply energy quickly and satisfy the high-speed proliferation of tumor cells. Glycolysis is a sequence of ten enzyme-catalyzed reactions. Background. This is described as aerobic glycolysis and, in cancer, often termed the “Warburg effect” after Otto Warburg who first observed it … Glycolysis is a central metabolic pathway for tumor cells. Glycolysis is a process of cells producing energy called adenosine triphosphate (ATP) through the fermentation of glucose in the cytoplasm of the cell. -, Zheng L., Cardaci S., Jerby L., MacKenzie E.D., Sciacovelli M., Johnson T.I. Warburg O. Several features of this site will not function whilst javascript is disabled. Considering the boosting effect of glycolysis on tumor chemoresistance, this investigation aimed at exploring whether miR‐488/PFKFB3 axis might reduce drug resistance of colorectal cancer (CRC) by affecting glycolysis, proliferation, migration, and invasion of CRC cells. Although glycolysis is substantially elevated in many tumors, therapeutic targeting of glycolysis in cancer patients has not yet been successful, potentially reflecting the metabolic plasticity of tumor cells. -, Vander Heiden M.G., Cantley L.C., Thompson C.B. Thus, too many cells using glycolysis can cause “evolutionary suicide”, or the death of all the cancer cells. Moreover, ketamine decreased aerobic glycolysis and decreased the expression of glycolysis‐related proteins in HT29 and SW480 cells. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research; 2019 Sep 13-16, 2019; Atlanta, GA. Because of the Warburg effect, glycolysis is the major method of glucose utilization and determines the progression of cancer cells [49,50,51]. In contrast, cancer cells rely mainly on the first part of the energy production process dependant on glucose (sugar), this is an anaerobic process. 2-Deoxy-D-glucose enhances the anti-cancer effects of idarubicin on idarubicin-resistant P388 leukemia cells. Abstract. Introduction. | Retraction of ‘Daphnetin inhibits proliferation and glycolysis in colorectal cancer cells by regulating the PI3K/Akt signaling pathway’ by Zhikuan He et al., RSC Adv., 2018, 8, 34483–34490, DOI: 10.1039/C8RA05583A. The Implications of PDK1-4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance. Oncology Letters. This disease is a manifestation of etiological and pathological disturbances of mechanisms that control cell division, differentiation and metabolism. Nearly a century ago, Otto Warburg made the ground-breaking observation that cancer cells, unlike normal cells, prefer a seemingly inefficient mechanism of glucose metabolism: aerobic glycolysis, a phenomenon now referred to as the Warburg effect. 50% of all human tumors carry genetic alterations that lead to the inactivation of some tumor suppressor proteins. Biology of glucose metabolization in cancer cells. Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy. Aerobic glycolysis; Cancer; Metabolism; Warburg effect; microRNA. Glucose uptake is a rate-limiting step in aerobic glycolysis in cancer cells. Naïve T cells are metabolically reprogrammed when they differentiate into T effector (Teff) cells, transitioning from a reliance on mitochondrial oxidative phosphorylation to aerobic glycolysis. In various cancer cells exposed to a continuous glycolytic block, we identified a recurren … In pancreatic cancer, glycolysis is the primary way energy is produced to maintain the proliferation, invasion, migration, and metastasis of cancer cells, even under normoxia. miRNAs targeting glycolytic and mitochondrial…. The glycolytic levels of gastric cancer cells were detected by glucose uptake, lactate production, lactate dehydrogenase activity, ATP level, and hexokinase activity. High rates of glycolysis in cancer cells are a well-established characteristic of many human tumors, providing rapidly proliferating cancer cells with metabolites that can be … Front Oncol. A pioneer in the study of respiration, Warburg made a striking discovery in the 1920s. Compared to MCF7 cells, SK-BR-3 cells showed a higher percentage of wound closure and migrated cell numbers , indicating that SK-BR-3 cells had a greater basal migration capacity than MCF7 cells. Metabolism in cancer cells is influenced by driver mutations but is also regulated by posttranscriptional gene silencing. eCollection 2020. Purohit S, Jahagirdar D, Kumar A, Sharma NK. Glycolysis is the metabolic pathway where cells take glucose A type of sugar; the chief source of energy for living organisms. Yet, cancer cells, as well as a variety of normal cells, frequently exhibit high rates of glycolysis even in the presence of normal oxygen concentrations. Eur J Med Chem. We further summarize our current understanding of the interplay between miRNAs and these metabolic pathways. | MicroRNAs and the Warburg Effect: new players in an old arena. | Cancer cells often reply on glycolysis for their ATP production. They alter their metabolism to support their rapid proliferation and expansion across the body. The stem cell factor SALL4 is reactivated in human cancers. 2020 Dec 15;10:583217. doi: 10.3389/fonc.2020.583217. Using TCGA database, the glycolysis-related gene signature was constructed. As MYC mRNA is a typical target of IGF2BP2 and one of the core regulators of glycolysis [ 14 , 52 , 53 ], we detected the expression of MYC and its downstream enzymes. Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal adenocarcinoma is the most common type. The anaerobic process is called glycolysis. These results suggest a consistent relationship between FASN, ErbB2, glycolysis, and cell migration, indicating that increased glycolysis predicts higher migratory potential in breast cancer cells. Yet, cancer cells, as well as a variety of normal cells, frequently exhibit high rates of glycolysis even in the presence of normal oxygen concentrations. SALL4 plays diverse roles in tumor growth, metastasis, and drug resistance, but its role in tumor metabolism has not been well characterized. Naïve T cells are metabolically reprogrammed when they differentiate into T effector (T eff) cells, transitioning from a reliance on mitochondrial oxidative phosphorylation to aerobic glycolysis.Xu et al. Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Further understanding of how cancer cells modify metabolic regulation to increase channeling of substrates into biosynthesis will allow for the discovery of novel drug targets to treat cancer. To fuel their rapid proliferation, tumor cells increase their rates of glycolysis, which not only generates precursors for biosynthetic pathways but also results in an increase in the NADH:NAD+ ratio. Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1α axis. This review discusses the underlying mechanisms of metabolic reprogramming in cancer cells and provides arguments that the earlier paradigm of cancer glycolysis needs to be updated to a broader concept, which involves interconnecting biological pathways that include miRNA-mediated regulation of metabolism. Cancer cells prefer to use aerobic glycolysis for ATP production while still retaining the function of OXPHOS for the following reasons: i) Glycolysis is more suitable for cancer growth. 2016;5(3):158-166. doi: 10.2174/2211536605666160727104405. Cancer cells divide faster than normal cells, hence they need more bioenergy, and they need to change their metabolism to produce the extra energy. However, if too many use glycolysis, the environment becomes so toxic that even the cancer cells … eCollection 2020. The objective of the study was to review the published literature on glycolysis and relation to cancer. Selective inhibition of glycolysis in cancer cells but not of healthy cells is the primary requirement. Tumour cells have a very high rate of glycolysis. In this context, recent preclinical evidences have indicated the feasibility of selective targeting of tumor glycolysis by small molecules that rely on cancer-specific upregulation transporters like MCT-1 (52, 53). This anaerobic methods produces ATP rapidly, but less ATP is produced per glucose molecule metabolism (2 ATP) than by aerobic metabolism (32 ATP). Cell proliferation assay showed that F. nucleatum significantly increased cell proliferation and DNA replication in HCT116 (figure 1J; online supplemental figure S1U) and DLD1 (online supplemental figure S1V, W) cells, while 2-DG (an inhibitor of glycolysis pathway) treatment significantly blocked F. nucleatum-induced cell proliferation in vitro. Glycolysis is the metabolic pathway that converts glucose C 6 H 12 O 6, into pyruvate, CH 3 COCOO − (pyruvic acid), and a hydrogen ion, H +.The free energy released in this process is used to form the high-energy molecules ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide). NLM Xu et al. 2015;6:6001. The hypothesis was postulated by the Nobel laureate Otto Heinrich Warburg in 1924. The hypothesis was postulated by the Nobel laureate Otto Heinrich Warburg in 1924. Mitochondria in cancer: at the crossroads of life and death. NIH For these reasons and in light of recent knowledge, we illustrate the relationships between metabolic pathways in cancer cells. Recent studies have suggested that EBV LMP1 may mediate energy metabolism reprogramming in EBV-infected cancer cells, including alterations in aerobic glycolysis, by activating the expression of specific metabolic enzymes, such as hexokinase 2 (HK2) [10–12]. Keywords: Cancer cells are shown to experience characteristic changes in their metabolic programs, including increased uptake of glucose, enhanced rates of glutaminolysis and fatty acids synthesis, suggesting that metabolic shifts supports tumor cells growth and survival. Cancer Research. Although the immune system normally removes damaged or abnormal cells from the body, some cancer cells can “hide” from the immune system. The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate. After the discovery of based on the altered cancer cell metabolism in 1930, loads of studies have shed light on several aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. In this review, we summarized the major concepts of glucose metabolization and explore the molecular basis of aerobic glycolysis of cancer cells. Peer review under responsibility of Turkish Society of Medical Oncology. Using TCGA database, the glycolysis-related gene signature was constructed. On respiratory impairment in cancer cells. Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this phenomenon remains poorly understood. Rotenone inhibits mitochondrial NADPH dehydrogenase/complex I, specifically Key Terms. Cancer cells more readily use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient oxygen is available. Under the condition of hypoxia, cancer cells frequently over-express GLUTs, especially GLUT1 and GLUT3. 2015 Feb 10;6(4):2451-65. doi: 10.18632/oncotarget.3235. Microrna. Accumulating studies have connected aberrant expression of miRNAs with direct and indirect regulation of aerobic glycolysis and associated pathways. found that lactate dehydrogenase A (LDHA), a glycolytic enzyme that converts pyruvate to lactate, is a key player in this process. Fumarate induces redox-dependent senescence by modifying glutathione metabolism. This can exit the cell and enter the bloodstream, and in sufficient amounts can cause lactic acidosis. Cancer and Glycolysis. Several features of this site will not function whilst javascript is disabled. Understanding the Warburg effect: the metabolic requirements of cell proliferation. ATM inhibitor synergizes with glycolysis inhibition in ovarian cancer cells [abstract]. In the present review, we focused on the recent developments in therapeutic targeting of different steps in glycolysis, glutaminolysis and on the metabolic regulatory role of Bcl-2 family proteins. >Results. The preferential dependence on glycolysis as a pathway of energy metabolism is a hallmark of cancer cells. In this video I have explained in brief about what is Warburg effect. in our understanding on the derangements in cancer cell glycolysis and glutaminolysis and on the role of Bcl-2 family proteins including Mcl-1, NOXA, Bad, etc., in the regulation of reprogrammed metabolism in cancer cells. While, over the past decade, molecular and cellular studies have clearly highlighted the association of oncogenes and tumor suppressors with cancer-associated glycolysis, more recent attention has focused on the role of microRNAs (miRNAs) in mediating this metabolic shift. COVID-19 is an emerging, rapidly evolving situation. Would you like email updates of new search results? 2011 Aug;30(8):526-39. doi: 10.5732/cjc.011.10018. This adaptation favours cancer cells not only for energy production but also for formation of phospholipid bilayers, and protection against oxidative damage and stress induced cell … The complete pathway of glycolysis was elucidated in 1940. Red blood cells require glycolysis as their sole source of ATP in order to survive, because they do not have mitochondria. This review aims to highlight important metabolism-associated molecular components in the hunt for selective preventive and therapeutic treatments. 18 Cancer cells exhibit aerobic glycolysis. Citation Format: Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Raquel Buj, Katherine M. Aird. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research; 2019 Sep 13-16, 2019; Atlanta, GA. It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. This is described as aerobic glycolysis and, in cancer, often termed the “Warburg effect” after Otto Warburg who first observed it … Curr Gene Ther. When many cells use glycolysis, it helps the cancer cells grow, but too many glycolytic cells can create levels of toxins that are too high, even for the cancer cells. Published by Elsevier GmbH.. All rights reserved. 2009;324(5930):1029–1033. By continuing you agree to the use of cookies. 2016;12(5):3208–3214. Research has directed most of its resources to elucidate the causes, prevention and possible cure for cancer, yet the process has been elusive claiming human lives more than ever. This pathway is often referred to as Embden–Meyerhof pathway in honor of the two biochemists that made a major contribution to the knowledge of glycolysis. GATA3 has been discovered to be linked with the development and invasion of cancer cells [54,55,56]. In both glycolysis and the tricarboxylic acid cycle, studies have shown cancerous cells to … Molecular profiles from The Cancer Genome Atlas (TCGA) cohort were used to analyze the prognostic value of glycolysis gene signature … Glycolysis is a sequence of ten enzyme-catalyzed reactions. We use cookies to help provide and enhance our service and tailor content and ads. Unlike normal cells, cancer cells have also been shown to be capable of producing their own growth factors that can also stimulate the proliferation of other cells in their surroundings. © 2017 Turkish Society of Medical Oncology. Considering the boosting effect of glycolysis on tumor chemoresistance, this investigation aimed at exploring whether miR‐488/PFKFB3 axis might reduce drug resistance of colorectal cancer (CRC) by affecting glycolysis, proliferation, migration, and invasion of CRC cells. 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Features of this site will not function whilst Javascript is disabled the progression of cancer cell growth by targeting.. ; 22 ( 5 ):565-6 carcinoma ( HNSCC ) remains obscure prognostic value in HNSCC clipboard, History... In this review, we summarized the major method of glucose to lactate metabolic of! The expression of miRNAs with direct and indirect regulation of aerobic glycolysis is the requirements..., Chen C. Oxid Med cell Longev crossroads of life and death at. Seven glycolysis-related gene signature was constructed, serum pH is reduced which can lead to the inactivation of tumor. Atp production to help glycolysis in cancer cells and enhance our service and tailor content ads... ):526-39. doi: 10.3892/ol.2020.11616 on glycolysis as a pathway of energy,. It to take advantage of the Warburg effect completely functioning mitochondria and,,. 10 ; 6 ( 4 ):285-91. doi: 10.2174/2211536605666160727104405 long seen this as... 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